Article ID Journal Published Year Pages File Type
3376222 Journal of Infection 2007 4 Pages PDF
Abstract

SummaryWe report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD). Since the introduction of tumor necrosis factor-alpha (TNF-α) antagonists, various microbiologic agents have been reported to cause pneumonia following their administration. To our knowledge, AVP following therapy with TNF-α antagonists has not been reported in English literature. We present a brief review of the mechanism of action of TNF-α antagonists and their ability to predispose to various infections including viral pneumonia by interfering with the immune response.

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