Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3376574 | Journal of Infection | 2006 | 6 Pages |
Abstract
SummaryA multidrug-resistant Pseudomonas aeruginosa (r-Pa) was isolated from a lethal case of sepsis in a bone marrow transplant recipient. Genotypic analysis of P. aeruginosa isolates demonstrated that sepsis was secondary to gut colonization. The interactions between r-Pa and patient's neutrophils were studied. The results indicate that: (1) the patient's neutrophil killing activity and nitric oxide production against r-Pa or drug sensitive P. aeruginosa (s-Pa) were profoundly impaired; (2) r-Pa cells, but not s-Pa cells or their filtered culture supernatants, induced necrosis of healthy donor neutrophils. Neutrophil necrosis emerges as a remarkable event in the pathogenesis of P. aeruginosa sepsis.
Keywords
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Authors
Antonella Mencacci, Elio Cenci, Antonella Repetto, Rosanna Mazzolla, Francesco Bistoni, Franco Aversa, Teresa Aloisi, Anna Vecchiarelli,