| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3378341 | Journal of Microbiology, Immunology and Infection | 2011 | 7 Pages |
BackgroundCandidemia caused by non-albicans Candida spp. is of special concern because of its high drug resistance and increase in prevalence. In clinical practice, early identification of non-albicans candidemia is crucial. We investigated the outcome in patients with candidemia caused by Candida albicans and Candida non-albicans.MethodsWe retrospectively evaluated candidemic patients from October 2007 to July 2009. Underlying diseases, predisposing factors, laboratory data, and outcome were analyzed.ResultsOne hundred and eight patients of candidemia were enrolled. Candida albicans and non-albicans spp. were responsible for 56.5% (61 of 108) and 43.5% (47 of 108) of candidemia cases, respectively. Among patients with non-albicans candidemia, significantly more patients had neutropenia (p = 0.001) and less patients had candiduria (p = 0.001) and intensive care unit stay (p = 0.002) in comparison with those with C albicans candidemia. All-cause Day 7 mortality was high in both C albicans and non-albicans spp. candidemia [44.3% (27 of 61) vs. 29.8% (14 of 47)]. Multivariate analysis revealed that poor renal function (odds ratio, 1.035; 95% confidence interval, 1.001–1.071; p = 0.04) and shock (odds ratio, 19.4; 95% confidence interval, 2.53–149.5; p = 0.004) are independent risk factors for fatal candidemia.ConclusionsThe outcome of candidemia was poor. The identified risk factors may help us to differentiate fatal candidemia in early infection.
