| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3383870 | Reumatología Clínica | 2006 | 6 Pages |
Abstract
The use of stem cell transplantation for severe autoimmune diseases refractory to conventional therapy arose from two discoveries: the excellent results of animal experiments, and serendipitous observations in human coincidental diseases. Experimental data and early phase I-II trials in highly selected patients suggest that highdose chemotherapy followed by autologous hematopoietic stem cell transplantation can arrest progression of severe autoimmune diseases with an acceptable risk/benefit ratio. The present article reviews the phase II-III prospective, multicenter, randomized trials that have been performed in distinct autoimmunediseases. In addition, allogeneic stem cell transplantation for autoimmune diseases is being cautiously explored in current protocols.
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Authors
Alicia GarcÃa López, Ildefonso Espigado Tocino, Natalia Cid Boza,