| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3385340 | Revista Colombiana de Reumatología | 2016 | 18 Pages |
Abstract
The BAFF complex (B cell activator factor) composed by the BAFF cytokine, APRIL and their receptors -BAFF-R (BR3), TACI, BCMA- influences B-lymphocyte maturation, peripheral survival and immunoglobulins class isotype switching, with multiple potential clinical implications. In this review we discuss BAFF biologic functions and it relevance in several clinical disorders -autoimmune, neoplastic, infectious and BAFF therapies-. BAFF/APRIL serum levels are increased in autoimmune diseases where their concentrations are related with disease antibodies titles, activity, progression and inclusive organic compromise, making its inhibition an important therapeutic target.
Related Topics
Health Sciences
Medicine and Dentistry
Immunology, Allergology and Rheumatology
Authors
Fabio Enrique Ospina, Juan Felipe Betancur, Juan Pablo Suso, Evelyn Muñoz-Buitron, Carlos Alberto Cañas, Gabriel J. Tobón,