Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3385535 | Revista Colombiana de Reumatología | 2011 | 7 Pages |
Abstract
Ochronosis is the manifestation of alkaptonuria in the connective tissue. It is originated by the alteration in the metabolism of homogentisic acid, a product of autosomal recessive mutation of HGO, gene in the long arm of chromosome 3 (3q21-23). It is a rare disease, characterized by the presence of calcifications in the intervertebral discs and deposit of homogentisic acid in connective tissue and tendons. We present two compatibles cases with the clinical and radiological features of ochronosis.
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Authors
Rosa MD, John MD, Elsa MD, Paola MD, Wilson A. MD, Claudia M. MD, Enrique MD, Rafael MD,