Espondiloartritis y su asociación con el Complejo Mayor de Histocompatibilidad “Spondylarthritis and the association with Major Histocompatibility Complex”

Ankylosing Spondylitis as a prototype of Spondylarthritis is an inherited disease with 90% of susceptibility related to genetic factors. Since the publication of the association of HLA-B*27 in the 70's, the molecular component of this association, one of the strongest between a molecule of Major Histocompatibility Complex and disease, remains unclear. The strong association of HLA-B*27 gives to this allele a significant role in susceptibility related to disease development. Several studies have reported the association of other genes within the Major Histocompatibility Complex to susceptibility for development of the disease in others population groups.