Article ID Journal Published Year Pages File Type
3386556 Revue Française d'Allergologie 2012 4 Pages PDF
Abstract
Severe asthma is currently defined as asthma that is not controlled in spite of intensive therapy. Nevertheless, there are different phenotypes of severe asthma. The phenotypes are distinguished according to the way in which the absence of control is defined: by severe acute exacerbations; by an early, persistent obstructive syndrome, sometimes accompanied by a rapid decline of respiratory function during the course of infancy; by an association of the two preceding types, especially in cases with partial or total corticosteroid resistance. In children, atopy is often responsible for these severe asthma phenotypes, and also for the persistence of asthma through the course of infancy and then into adulthood.
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