Association Between Joint Hypermobility Syndrome and Panic Disorder: A Case–Control Study

BackgroundA significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients.ObjectiveThe aim of this study was to assess whether JHS is more frequent in panic-disorder than in control subjects.MethodThe authors conducted a case–control study comparing 55 untreated patients with panic disorder and three matched-control groups: psychiatric patients, fibromyalgia patients, and healthy persons.ResultsJHS was more frequent among panic-disorder than among psychiatric patients, the healthy group, or the fibromyalgia group. In the panic-disorder group, there was a significant correlation between severity of JHS and anxiety.ConclusionThe strong association between JHS and panic disorder points to a genetic association. There is also a possibility that JHS and mitral valve prolapse, another condition frequently associated with panic disorder, share a common pathophysiological mechanism.