| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 338897 | Schizophrenia Research | 2016 | 5 Pages |
Abstract
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a recently-discovered synaptic autoimmune disorder in which auto-antibodies target NMDARs in the brain, leading to their removal from the synapse. Patients manifest with prominent psychiatric symptoms – and in particular psychosis – early in the disease course. This presentation converges with long-standing evidence on multiple fronts supporting the glutamatergic model of schizophrenia. We review mechanisms underlying disease in anti-NMDAR encephalitis, and discuss its role in furthering our understanding of neural circuit dysfunction in schizophrenia.
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Authors
Matthew S. Kayser, Josep Dalmau,