Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3390732 | Rheumatic Disease Clinics of North America | 2008 | 13 Pages |
Abstract
Sjögren's syndrome is a chronic inflammatory disease primarily affecting the exocrine glands. Its association with lymphoma is well documented, with salivary extranodal marginal zone lymphomas of the mucosa-associated lymphoid tissue type being the most common and constituting a major disease complication. These neoplasms are antigen-stimulated B-cell lymphomas characterized by localized stage, indolent clinical course, and recurrence in other extranodal sites. This article presents a review of the literature and discusses the clinical, histopathologic, therapeutic, and prognostic aspects of these tumors in Sjögren's syndrome. In addition, it highlights the predictor markers of lymphoma development.
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Authors
Michael Voulgarelis, Haralampos M. Moutsopoulos,