| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3391331 | Seminars in Immunology | 2015 | 16 Pages |
•Biosynthesis of specialized proresolving mediators (SPM).•Functions of resolvins, lipoxins, protectins and maresins.•SPM actions in animal models of disease.
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are each temporally produced by resolving-exudates with distinct actions for return to homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition. This review covers these SPM mechanisms and other new omega-3 PUFA pathways that open their path for functions in resolution physiology.
