Factors and networks that underpin early hematopoiesis

Multiple trajectories have recently been described through which hematopoietic progenitor cells travel prior to becoming lineage-committed effectors. A wide spectrum of transcription factors has recently been identified that modulate developmental progression along such trajectories. Here we describe how distinct families of transcription factors act and are linked together to orchestrate early hematopoiesis.

► Transcriptional control of hematopoiesis. ► Lineage specification and the role of transcription factors. ► Distinct transcription factors and B, T, or myeloid lineage specific programs of gene expression. ► Global studies of transcription factor binding sites in hematopoiesis.