On becoming a T cell, a convergence of factors kick it up a Notch along the way

The thymus is seeded by bone marrow-derived progenitors, which undergo a series of differentiation and proliferation events in order to generate functional T lymphocytes. The Notch signaling pathway, together with multiple transcription factors, act in concert to commit progenitors to a T-lineage fate, extinguishing non-T cell potential, inducing thymocyte differentiation and supporting proliferation and survival along the way to becoming a mature T cell. This review focuses on recent evidence regarding the complex interplay between the Notch pathway and other key transcription factors at specific lineage-decision points during the program of T cell development.

► This review highlights several important lineage commitment events that take place during intrathymic T cell development. ► The critical role of Notch signaling in initiating T-lineage commitment is discussed. ► The complex interplay between Notch and other key transcription factors is discussed.