Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391482 | Seminars in Immunology | 2009 | 5 Pages |
Abstract
The innate immune system senses danger signals via evolutionary conserved receptors. The nucleotide-binding domain leucine-rich repeat containing receptor (NLR) family is a group of intracellular receptors that drive a wide variety of inflammatory responses. A number of the NLR family members can form inflammasomes, which are multiprotein complexes that can activate caspase-1 and ultimately lead to the processing and secretion of interleukin (IL)-1β, IL-18 and IL-33. One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Suzanne L. Cassel, Sophie Joly, Fayyaz S. Sutterwala,