Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391486 | Seminars in Immunology | 2009 | 10 Pages |
Abstract
Mitochondria have been long recognized for their key role in the modulation of cell death pathways. Thus, it is therefore not surprising that this organelle represents a recurrent target for pathogenic microbes, aiming to manipulate the fate of the infected host cell. More recently, mitochondria have been shown to serve as a crucial platform for innate immune signaling, as illustrated by the identification of MAVS (also known as IPS-1, VISA and Cardif), NLRX1 and STING as mitochondrial proteins. This review discusses the tight interplay between microbial infection, innate immune signaling and mitochondria.
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Authors
Damien Arnoult, Leticia Carneiro, Ivan Tattoli, Stephen E. Girardin,