Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391519 | Seminars in Immunology | 2009 | 6 Pages |
Abstract
Vitamin A protects against development of infectious diseases, and B cells are important players in this process. Keys to the protective role of retinoic acid (RA) against infections appear to be its ability to enhance antibody responses against T-cell dependent and independent type 2 antigens, as well as to locally stimulate IgA production in mucosal tissues. The elucidation of molecular mechanisms involved in RA-mediated regulation of proliferation and differentiation of B cells not only helps us to understand how RA differentially regulates subsets of B cells, but might also lead to more targeted treatment of selected immune disorders and B cell malignancies.
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Authors
Åse Ertesvåg, Soheil Naderi, Heidi Kiil Blomhoff,