| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3391572 | Seminars in Immunology | 2010 | 9 Pages |
Abstract
Notch signaling plays multiple roles in T cell development. Following thymic entry, Notch signals are required to specify the T cell fate from a multipotent hematopoietic progenitor. At subsequent steps in early T cell development, Notch provides important differentiation, survival, proliferation and metabolic signals. This review focuses on the multiple functions of Notch in early T cell development, from T cell specification in the thymus through beta selection.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Yumi Yashiro-Ohtani, Takuya Ohtani, Warren S. Pear,