Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391651 | Seminars in Immunology | 2009 | 9 Pages |
Abstract
Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Erika Wissinger, John Goulding, Tracy Hussell,