| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3391653 | Seminars in Immunology | 2009 | 8 Pages |
Abstract
CD4+ TH17 cells display a featured role in barrier immunity. This effector population of T cells is important for clearance of microorganisms but can also promote autoimmunity at barrier sites. Recent work has indicated that these effector cells share a pathway with CD4+ regulatory T cells (TR cells) that also have a critical function in barrier protection and immune regulation. The development and function of TH17 cells, and their relationship with TR cells are discussed.
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Authors
Benjamin R. Marks, Joe Craft,