Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391708 | Seminars in Immunology | 2007 | 9 Pages |
Abstract
The mechanisms by which αβ T-cells are selected in the thymus and then recognize peptide MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with respect to quantification of T-cell sensitivity and the role of self-ligands in T-cell activation has provided some important clues to the details of how TCR signaling might be initiated. Here, we highlight recent experimental data that provides insights into the initiation of T-cell activation and also discuss the main controversies and uncertainties in this area.
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Authors
Michelle Krogsgaard, Jeremy Juang, Mark M. Davis,