| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3391717 | Seminars in Immunology | 2007 | 8 Pages |
Abstract
Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS.
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Authors
Gabrielle L. Goldberg, Johannes L. Zakrzewski, Miguel A. Perales, Marcel R.M. van den Brink,