Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391722 | Seminars in Immunology | 2007 | 9 Pages |
Abstract
Immunodeficient individuals are susceptible to opportunistic infection. While stem cell transplantation can restore a functional immune system, T cells are slow to recover and limited in eliciting adaptive immune responses. Approaches to selectively enhance T cell function have focused on boosting thymopoiesis to generate new T cells or expanding existing T cells. By taking advantage of the role of Notch signaling in T cell development, we have developed an in vitro system able to generate large numbers of progenitor T cells from human hematopoietic stem cells. Here, we discuss this in vitro system and its implications for the potential treatment of T cell immunodeficiency.
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Authors
Génève Awong, Ross N. La Motte-Mohs, Juan Carlos Zúñiga-Pflücker,