Article ID Journal Published Year Pages File Type
3391765 Seminars in Immunology 2007 11 Pages PDF
Abstract

Several events control the activation, proliferation, and the continued Ag responsiveness of naïve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.

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Life Sciences Immunology and Microbiology Immunology
Authors
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