Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391765 | Seminars in Immunology | 2007 | 11 Pages |
Abstract
Several events control the activation, proliferation, and the continued Ag responsiveness of naïve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.
Keywords
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Authors
Anna Mondino, Daniel L. Mueller,