Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391858 | Seminars in Immunology | 2006 | 8 Pages |
Abstract
B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted into antibody-producing plasma cells. B cell differentiation involves multiple steps, including cell specification, commitment to the B cell lineage, immunoglobulin rearrangements, maturation of B cells and terminal differentiation into plasma cells. Each of these steps is controlled by signaling pathways and transcription factors that act in synergy, feedback-loops or cross-antagonism to generate complex regulatory networks that allow for plasticity and stability of B cell differentiation.
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Authors
Stephanie Roessler, Rudolf Grosschedl,