Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3391863 | Seminars in Immunology | 2006 | 11 Pages |
Abstract
B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and mouse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation. In addition, the mechanisms triggering pre-BCR activation are reviewed, taking into account the recent report of heparan sulfates and galectin 1 as stromal cell-derived pre-BCR ligands. Finally, ligand-induced pre-BCR activation models are proposed on the bases of the differences reported for pre-BCR and IL7 dependencies in the two species.
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Authors
Marion Espeli, Benjamin Rossi, Stéphane J.C. Mancini, Philippe Roche, Laurent Gauthier, Claudine Schiff,