Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3392020 | Transplant Immunology | 2015 | 5 Pages |
Abstract
•Originality of this work relies in comparison of evolution with time of anti-HLA antibodies in serum and graft to try to understand graft dysfunction.
The current literature suggests that anti-HLA donor-specific antibodies (DSA) may have deleterious effects on liver grafts but there is no proof that they are directly involved in the graft lesions. We report the case of a donor HLA-sensitized patient who needed a second graft 6 months after the first transplantation owing to a progressive cholestatic disease that we could finally attribute to antibody-mediated rejection (AMR). We describe the longitudinal evolution of graft function, tissue histology, serum DSA and, for the first time, intra-graft DSA after elution from biopsies.
Keywords
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Immunology
Authors
Martine Neau-Cransac, Brigitte Le Bail, Gwendaline Guidicelli, Jonathan Visentin, Karine Moreau, Alice Quinart, Anna Boueilh, Christophe Laurent, Jean-Luc Taupin,