| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3392142 | Transplant Immunology | 2012 | 7 Pages |
BackgroundThe published data revealed conflicting results of the polymorphism of MDR1 exon 26 SNP C3435T on the pharmacokinetics of tacrolimus in different post transplant times; thus, the aim was to perform a meta-analysis of different post transplant times to investigate the influence of SNP C3435T on the tacrolimus pharmacokinetics.MethodsA literature search was conducted to locate the relevant papers by using the PUBMED and EMBASE electronic source until 2011. The pharmacokinetic parameters, including dose administration, concentration and concentration to dose ratio were extracted and a meta-analysis was performed by using STATA10.0.ResultsA total of 13 papers concerning 1327 individuals were included in the meta-analysis. The overall results showed SNP C3435T could influence the pharmacokinetic parameters in different post transplant times, the subjects with CC genotype had lower concentration dose ratio and need higher tacrolimus dose than the CT and TT genotype.ConclusionsOur meta-analysis of available studies has demonstrated a definite correlation between the SNP C3435T in MDR1 gene and pharmacokinetics of tacrolimus. However, additional studies with large sample size and better study designs are warranted to verify our finding.
► MDR C3435T could influence the pharmacokinetic parameters of tacrolimus in different post transplant time. ► The recipients with CC genotype had lower tacrolimus concentration dose ratio. ► The recipients with CC genotype need higher tacrolimus dose than the CT and TT genotype.
