Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3392309 | Transplant Immunology | 2009 | 5 Pages |
Abstract
Accommodation refers to the condition in which an organ transplant functions normally by acquiring resistance to immune-mediated injury (especially), despite the presence of anti-transplant antibodies in the recipient. This status is associated with several modifications in the recipient as well as in the graft, such as previous depletion of anti-graft antibodies and their slow return once the graft is placed; expression of several protective genes in the graft; a Th2 immune response in the recipient; and inhibition of the membrane attack complex of complement.
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Authors
Jean-Paul Dehoux, Pierre Gianello,