Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3392387 | Transplant Immunology | 2009 | 4 Pages |
BackgroundLevels of sCD30 represent a biomarker for early outcome in kidney transplantation. The purpose of this study was to determine the role of sCD30 levels for prediction of graft loss in the late post-transplant period.MethodsSera were collected immediately pre-transplant and yearly thereafter for up to 5-year post-transplant in 37 primary renal transplant recipients. Levels of serum sCD30 were tested using a fluorescent microsphere assay.ResultsLevels of sCD30 significantly decreased after transplantation and remained normal in 34 patients without graft loss up to 5-year post-transplant. Elevated levels of serum sCD30 preceded the increase of serum creatinine in patients with subsequent graft loss.ConclusionsElevated levels of serum sCD30 post-transplant might be a marker for predicting subsequent graft loss in the post-transplant period.