Perimenopausal Postpartum Depression After Conception by Assisted Reproductive Technology

BackgroundWomen conceiving after the onset of the menopausal transition may experience hormonal fluctuations that predispose them to postpartum depression. Conception by assisted reproductive technology (ART) may increase this risk.ObjectiveThis case report highlights the hormonal and pathophysiological changes that may contribute to the development of postpartum depression during perimenopause.MethodThe authors report on the case of a perimenopausal woman who developed postpartum depression after conception by ART.ResultsThe patient responded well to antidepressant treatment, estrogen replacement, and psychotherapy.ConclusionResearch into perimenopausal postpartum depression in the setting of ART may lead to improved screening and treatment for at-risk patients.