| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3393915 | Acta Tropica | 2012 | 5 Pages |
The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 0.97 ± 0.2 and 1.73 ± 0.5 μg/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC50 value of 12.0 μg/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2-arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC50 < 10 μM) and free radical scavenging (EC50ca. 10 μM) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% chemosuppression. In the same in vivo test, marginal activities were also observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina sacleuxii.
Graphical abstractBurttinol A (1) and burttinol D (4), among other flavonoids, have been identified as the antiplasmodial and radical scavenging principles in the roots of Erythrina burttii.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The root bark extract of Erythrina burttii showed in vitro antiplasmodial activity. ► The root bark extract of Erythrina burttii showed Radical scavenging activity against DPPH radical. ► Flavonoids were identified as the active antiplasmodial and free radical scavenging principles. ► The extracts of E. burttii, E. abyssinica and E. sacleuxii showed in vivo antimalarial activities.
