Does serum 25 hydroxy vitamin D level play a role in COPD?

It has been recognized that, in addition to its classical function, vitamin D modulates a variety of processes and regulatory systems including host defense, inflammation, and immunity. Some authors concluded that there is strong relation between vitamin D serum level and lung functions but others concluded that there is no relation between them.Aim of the workTo study the role of serum level of 25 hydroxy-vitamin D in COPD patients, also, assess the serum level of vitamin D dependent LL-37 and IFNγ and to study the link between the three parameters and pulmonary functions in these patients.Subjects and methodsThis study was conducted on 40 persons who were divided into GI, 10 controls and GII, 30 COPD patients. FEV1, serum levels of 25 hydroxy vitamin D, LL-37 and IFNγ were measured.ResultsSerum levels of 25 hydroxy vitamin D and LL-37 were significantly decreased in GII as compared to GI while serum level of IFNγ was significantly increased in GII as compared to GI and there was a significant positive correlation between vitamin D level and FEV1 and LL-37 level while there was a negative correlation between it and IFNγ level.ConclusionVitamin D level affects pulmonary function in COPD through its effect on LL-37 and IFNγ serum level.