Assessment of eotaxin 1 in exhaled breath condensate of chronic obstructive pulmonary disease patients

The aim of this work was to assess eotaxin 1 level in exhaled breath condensate of exacerbated and stable COPD patients in relation to normal subjects.Subjects and methodsThere were 16 COPD patients (during infective exacerbation), 16 stable COPD patients and 20 healthy volunteers as controls matched with them in age, sex and smoking history. EBC was collected and concentration of eotaxin 1 was measured by using Human Eotaxin 1 ELISA Kits.ResultsThe mean eotaxin 1 concentration in exhaled breath condensate of studied groups was 962.5 ± 150 pg/ml in the exacerbated COPD group, 427.8 ± 186.6 pg/ml in the stable group and 89.2 ± 47.5 pg/ml in the control group. Age, smoking, FVC, FEV1, and FEV1/FVC, showed no significant correlation with eotaxin 1 levels among all the studied groups.ConclusionEotaxin 1 levels in exhaled breath condensate of COPD patients during infective exacerbation was significantly higher than in stable COPD patients and both groups showed significant higher levels than the control group.