| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3400335 | Egyptian Journal of Chest Diseases and Tuberculosis | 2014 | 5 Pages |
Little is known about the effect of inhaled Mg sulfate when added to B2 agonist in acute asthma with pregnancy.Our objectiveTo evaluate the broncho-dilator effect of nebulized magnesium sulfate with B2 agonist in the treatment of acute asthma during pregnancy, and its safety on pregnancy outcome.Material and methodsThe studied patients were randomized into two groups. “Group A” patients received the routine treatment of acute asthma exacerbation plus nebulized salbutamol in dose of 1 ml of salbutamol solution dissolved in 9 ml of normal saline. “Group B” patients received the same above treatment plus 500 mg (1 ml) of magnesium sulfate. Two hours after therapy, pulmonary function test and blood gas analysis were done.ResultTotal 60 pregnant women with acute asthma, 30 patients in each group with mean age were 25.9 ± 4.01 and 25.7 ± 3.8. Comparison between both groups in pulse rate, arterial oxygen tension and oxygen saturation was significant (P < 0.001). FEV1 was 32.68 ± 7.15 and 56.31 ± 8.25 in groups A and B respectively and % of change was 69% with significant P value < 0.001. The frequency of asthma exacerbation till delivery was 3.2 ± 0.98 & 0.4 ± 0.57 in groups A and B respectively (95% CI 2.4–3.1) with significant P value (P < 0.001). All patients had either normal delivery (60% and 66.6%) or Cesarian (40% and 33.6%) with smooth neonatal period.In ConclusionAdding Nebulized Mgs for acute asthma during pregnancy is effective and safe. The availability, cheapness of this drug especially for the developing countries added to its advantage.
