Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3405738 | Journal of Global Antimicrobial Resistance | 2014 | 9 Pages |
Abstract
Successful meticillin-resistant Staphylococcus aureus (MRSA) clones have evolved to adapt to healthcare, community and livestock environments. This review will bring together recent studies into clone adaptation and the importance of genes acquired during horizontal gene transfer to survival in specific environments. It will also discuss the role of global regulators controlling virulence gene expression and resistance to antibiotics, such as the agr and vraRS systems. Understanding these processes in successful clones could reveal novel targets for therapeutic agents, which are urgently required to reduce the infection burden and improve treatment options.
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
S.M. Purrello, R.S. Daum, G.F.S. Edwards, G. Lina, J. Lindsay, G. Peters, S. Stefani,