| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3407465 | Journal of Virological Methods | 2009 | 4 Pages |
Abstract
BoHV-4 replication cycle is dependent on the S-phase of the cell-cycle at the stage of viral DNA synthesis. Because p21 is a rate-limiting regulator of the G1/S-phase transition and up-regulated by DNA-damaging agents, in this study p21 expression in BoHV-4 infected cells was investigated. The p21 promoter was found to be highly activated in a dose- and time-dependent manner following BoHV-4 infection only in cells which are permissive for BoHV-4 replication. Thus p21 expression reports on BoHV-4 replication and could represent a host cell defensive response to infection-associated cellular damage.
Keywords
Related Topics
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Immunology and Microbiology
Virology
Authors
A. Capocefalo, V. Franceschi, C.B.A. Whitelaw, D.B. Vasey, S.G. Lillico, S. Cavirani, G. Donofrio,