| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 340822 | Seizure | 2008 | 14 Pages |
SummaryIntroductionStatus epilepticus (SE) is frequently observed in epileptic patients. We reviewed a series of video-EEG documented SE to define the characteristics of SE in this population.Materials and methodsRetrospective evaluation of 50 epileptic patients with SE, revision of the electro-clinical data and therapies, and definition of the semeiological subtypes, aetiology, outcome and related epileptic syndromes.ResultsWe identified 28 convulsive (19 focal and 9 generalized) and 22 non-convulsive (8 focal and 14 generalized) SE patients. In 13 patients, SE was situation-related (poor compliance, AED reduction, worsening seizures).In the remaining 37 patients, SE was related to the natural history of epilepsy (progression of underlying pathologies or intrinsic expression of epileptic syndromes); in these last cases, our results show a higher occurrence in cryptogenic frontal epilepsy (p = 0.01). We identified two subgroups according to the duration of the event, i.e. SE lasting <12 h and SE lasting >12 h. Our results showed a worse response to therapy in SE lasting >12 h (p = 0.01), a better response to therapy in non-convulsive SE than in convulsive SE (p < 0.05) and a relationship at statistical significance limit between a poor response to therapy/worse outcome and symptomatic epileptic syndromes (p = 0.06).ConclusionSE in epileptic patients has a wide spectrum of electro-clinical features. It may be related to the withdrawal or reduction of AEDs, or may even be the expression of the evolution of epileptic syndromes. Response to therapy is dependent on early diagnosis and therapy.
