Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3414611 | Microbes and Infection | 2016 | 12 Pages |
Abstract
A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.
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Authors
Megha Gulati, Clarissa J. Nobile,