| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3414625 | Microbes and Infection | 2015 | 7 Pages |
Abstract
The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Kuo-Feng Weng, Po-Ting Hsieh, Hsing-I Huang, Shin-Ru Shih,