Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3414665 | Microbes and Infection | 2014 | 6 Pages |
Abstract
To determine if myeloid differentiation factor 88 (MyD88), which is necessary for signaling by most TLRs and IL-1Rs, is necessary for control of Pneumocystis infection, MyD88-deficient and wild-type mice were infected with Pneumocystis by exposure to infected seeder mice and were followed for up to 106 days. MyD88-deficient mice showed clearance of Pneumocystis and development of anti-Pneumocystis antibody responses with kinetics similar to wild-type mice. Based on expression levels of select genes, MyD88-deficient mice developed immune responses similar to wild-type mice. Thus, MyD88 and the upstream pathways that rely on MyD88 signaling are not required for control of Pneumocystis infection.
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Authors
Chiara Ripamonti, Lisa R. Bishop, Jun Yang, Richard A. Lempicki, Joseph A. Kovacs,