Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3414779 | Microbes and Infection | 2013 | 5 Pages |
Abstract
Ability of a cocktail of five lytic vibriophages to combatting Vibrio cholerae O1 infection in rabbit model was examined. In one group, rabbits were administered 1 × 108 plaque forming unit of phage cocktail 6 and 12 h prior to the administration of V. cholerae O1, while in the other group, same procedure was applied 6 and 12 h post infection. It was observed that oral administration of the phage cocktail after oral bacterial challenge lowered the shedding of bacteria significantly (p < 0.01). In contrast phage treatment prior to bacterial challenge had no such effect (p > 0.05). Results suggest that oral administration of phage subsequent to V. cholerae challenge could provide a possible means of combatting V. cholerae infection.
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Authors
Abhishek Jaiswal, Hemanta Koley, Amit Ghosh, Anup Palit, Banwarilal Sarkar,