Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3414923 | Microbes and Infection | 2011 | 6 Pages |
Abstract
Yeast-mediated protein delivery to mammalian antigen-presenting cells is a powerful approach for inducing cell-mediated immune responses. We show that coexpression of the pore-forming protein listeriolysin O from Listeria monocytogenes leads to improved translocation of a proteinaceous antigen and subsequent activation of specific T lymphocytes. As the resulting yeast carrier is self-attenuated and killed after antigen delivery without exhibiting any toxic effect on antigen-presenting cells, this novel carrier system suggests itself as promising approach for the development of yeast-based live vaccines.
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Authors
Barbara Walch, Tanja Breinig, Gernot Geginat, Manfred J. Schmitt, Frank Breinig,