Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3414993 | Microbes and Infection | 2011 | 5 Pages |
Abstract
Clinical protection of Beninese children against Plasmodium falciparum malaria was shown to be influenced by immunoglobulin (IG) Gm and Km allotypes, and related to seroreactivity with the rosette-forming VarO-antigenic variant. IgG to the VarO-infected erythrocyte surface, IgG1 and IgG3 to PfEMP1-NTS-DBL1α1-VarO were higher in the under 4-year-old children carrying the Gm 5,6,13,14;1,17 phenotype. In contrast, surface-reactive IgG, total IgG, IgG1 and IgG3 to NTS-DBL1α1- and DBL2βC2-VarO domains were lower in the above 4-year-old children harbouring the Km1 allotype. These data outline an age-related association of antibodies against malaria antigens and IG allotype distribution.
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Authors
Florence Migot-Nabias, Adjimon G. Lokossou, Inès Vigan-Womas, Evelyne Guitard, Micheline Guillotte, Julien M. Noukpo, Odile Mercereau-Puijalon, Jean-Michel Dugoujon, André Garcia,