Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415021 | Microbes and Infection | 2012 | 9 Pages |
Abstract
Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells and its consequences for toxin-mediated effects in rodent toxin and spore challenge models.
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Authors
Mahtab Moayeri, Inka Sastalla, Stephen H. Leppla,