Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415042 | Microbes and Infection | 2010 | 6 Pages |
Abstract
Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-α and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Anna Fialová, Zdeněk Cimburek, Giandomenica Iezzi, Jan Kopecký,