| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3415118 | Microbes and Infection | 2009 | 5 Pages |
Abstract
After activation, CD4+ helper T (Th) cells differentiate into cytokine-secreting effector subsets. A novel subset of CD4+ helper T (Th) cells that produce two related cytokines IL-17 and IL-17F has been recently identified and shown to play critical function in inflammation and autoimmunity. Here I summarize recent work by us as well as other investigators in understanding the transcriptional regulation of Th17-cell differentiation, their developmental relationship with regulatory T cells and the function of IL-17 and IL-17F in vivo.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Chen Dong,