Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3415190 | Microbes and Infection | 2009 | 9 Pages |
Abstract
We found that E-cadherins, α-catenin and β1-integrins were present at significant low levels in tissues of sheep affected by lepromatous form and that this pattern was associated with high expression of TGF-β, IL-10, IL-1β, and TNF-α and with a modest increase of CD4+ and CD25+ T cells. Tissues of sheep with the tuberculoid form showed high expression of IFNγ, IL-12, and MCP-1 and a significant presence of CD4+ and CD25+ T cells. Finally, anti-transglutaminase (tTG) IgG1 antibodies were detected in sera of infected animal belonging to both groups, as already described for human inflammatory bowel diseases. Our results further stress the similarities in the clinical and histological features between ruminant paratuberculosis and human intestinal inflammatory diseases.
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Authors
Giacomo Rossi, Giulia Nigro, Ivan Tattoli, Silvia Vincenzetti, Pierluigi Mariani, Gian Enrico Magi, Giacomo Renzoni, Ennio Taccini, Maria Lina Bernardini,