| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3415192 | Microbes and Infection | 2009 | 5 Pages |
Abstract
Six cats were inoculated with Bartonella henselae strains A and B, which were isolated from the same naturally infected cat. The numbers of CD4+ cells decreased following the infection. The levels of bacteremia were significantly correlated with the expression levels of IFN-γ mRNA during the various stages of bacteremia and elimination of the bacteremia. Furthermore, the lower levels of TNF-α mRNA expression during the bacteremia related to the emergence of higher levels of bacteremia. These results indicate that the activation of cell-mediated immune responses, including IFN-γ and TNF-α production, play an important role in elimination of B. henselae from bacteremic cats.
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Authors
Hidenori Kabeya, Tamao Umehara, Hiroki Okanishi, Izumi Tasaki, Misako Kamiya, Akihiro Misawa, Takeshi Mikami, Soichi Maruyama,