| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3415193 | Microbes and Infection | 2009 | 4 Pages |
Abstract
The CRNP5 variant of Borna disease virus (BDV) has stronger pathogenesis than the CRP3 variant in which only 4 nucleotides in the whole genome are different. The CRP3 is produced by 3 passages in rat brains of BDV, whereas the CRNP5 is produced by 5 passages in mouse brains after 2 passages in rat brains of the BDV. Thymidylic acids at nt 3608 and 3673 were replaced by cytidylic acids during 3 passages in mice. Three passages in mice caused replacement of adenylic acid at nt 7936 by guanylic acid. No replacement at nt 8742 occurred during passages in mice.
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Authors
Satoshi Okayama, Nanako Miura, Masaru Murakami, Masayuki Funaba, Yoshii Nishino,